PHARMACY EXAM
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Therapeutic index is
c- Toxic dose / therapeutic dose
Controlled drug in the body depend on
c- Body fluid interaction
Which of the following is enzyme inducer
a– Rifampicin
Which one is OTC drug
a– Analgesics
Anticoagulant effect of warfarin is decreased by the use of the following except
b- Aspirin
The steady state concentration of the drug in the plasma is
f- a+d
Drug physical dependence
a- As same as drug abuse
Bioavailability of the drug is
c- Rate & Extent of absorption
Example of drug induced hepatoxicity
a- Paracetamol
Examples of drug drug interaction
e- All of the above
Which one induces metabolism of other medication
d- Rifampicin
All of these you can dispense to patient without prescription except
b- Tegretol
Biotransformation process is
a- Transformation drug from more lipid soluble to less lipid soluble
Pharmacokinetics is
a- Effect of body on drug
The most common route of drug entry to the cell is
Hemisuccinate are used as prodrug for drugs to be given IV administration because
e- Both a and c
Intra osseous injection refers to injection into the
a- Bone marrow
Pharmacodynamic is defined by
e- All of the above
Drug -drug interaction may take place by the following mechanism(s)
e- All of the above
Biotransformation is conversion of the drug to
b- Less lipid soluble
Intrathecal is
a- Spinal cord
Which one is consider enzyme inducer
a- Rifampicin
Drugs that has narrow region between therapeutic and toxic dose
e- All of the above
OTC mean
(E) Both A & B
Which of the following drug inhibit activity of hepatic enzyme
(d) Cimetidine
Which of the following drug increase activity of hepatic enzyme
(E) All of above
Which of the following route give 100% bioavailability
(d) IV
Which of the following is the fastest dosage form
(c) IV injection
The site of (Intra-thecal injection ) is
(d) Directly in spinal cord
Mechanism of (Drug-Drug interactions) include
E) All of the above
The ……. Route offer instantaneous and complete absorbtion
(c) I.V
Drugs administered by ……. Are exposed to first pass metabolism
(b) Orally
The drug may be metabolized by
(d) Both A & B
The drug and its metabolites are eliminated from body in
(E) All of the above
The therapeutic index (TI) can be defined as :
(a) Toxic / effective dose
Which one of these is aprodrug?
(c) Levodopa
Pharmacokinetics include
(E) All of the above
Bioavailability is defined as
(b) Rate & extent to which drug enters systemic circulation
Total body clerancy is the sum of the clerance from :
(d) All of the above
All of the following affect drug distrubtion through lipid bilayer of the cell except
(a) Solubility in water
All are true about oral administeration of drug except
(c) Suitable for emetic cases
IV characterized by …….except
(a) Moderate velocity
IM is Suitable for………… except
(b) painful irritating drug
Intradermal injection is Suitable for………… except
(b) painful irritating drug
Plasma binding protein (PBP) of drug lead to ……. except
(d) No medicinal use of this drug
Binding of drug to Plasma binding protein (PBP) of drug characterized by
…….except
(a) Binding site is alpha glycoprotein
The aim of Drug metabolism is to convert the drug into
(b) Less toxic substance
Drug metabolism include ……… except
(b) Less or none ionized substance
Conjugation reaction for drug excretion will lead to
(a) Inactive substance
Drug metabolism mainly occur in
(d) Liver
Drug excretion mainly occur in
(a) Kidney
Mechanism of excretion of drug through kidney occur through all of them except
(a) Drug reabsorption from renal tubule
………. Study of drug and the way they interact with living system
A) Pharmacology
……….the exact description of chemical structure of drug
a) Chemical name
A drug may have different trade name but only one
a) Generic name
Which one of the following oral preparation give the fastest
systemic onset of action
d) Solution
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