Gp neelima hematology and oncology 2-02-17 Welcome to your Gp neelima hematology and oncology 2-02-17 Name Business Email Phone Number Macrocytosis is unlikely present in a patient having which of the following anemia? Reticulocytosis Vitamin B12 deficiency Sideroblastic anemia Folate deficiency Hint Hemolytic anemia is not characterized by Increased LDH Increased Reticulocytosis Increased haptoglobin Increased haptoglobin Hint A 44 year old X-ray technician is inadvertently exposed to 300 rads of radiation. The tissue types most likely to be sensitive to this level or radiation is Mature sperm Adrenal tissue Liver Lymphoid tissue Thyroid tissue Hint A 9 year old boy is brought to the physician because of recurrent epistaxis for the past 2 days. The child recently recovered from upper respiratory infection. Physical examination shows multiple mucosal petechiae, and several ecchymosis on the arms and legs. Organomegaly is not present. Investigations reveal normal PT, and aPTT, with a platelet count of 18,000. The most likely diagnosis is Bernard-Soulier syndrome Idiopathic thrombocytopenic purpura Thrombasthenia Von willebrand disease Wiskott -Aldrich syndrome Hint A 22 year old girl with no previous history of psychiatric illness or substance abuse is admitted for sudden onset of restlessness, visual and auditory hallucinations, and emotional lability. According to her parents she was treated with trimethoprim/sulfamethoxazole for a urinary infection 2 weeks ago. She has frequent abdominal pains and constipation. On physical examination, she looks pale, weak, diaphoretic, and is tachycardic. Symmetric bilateral weakness of the lower extremities is also present with greatly diminished tendon reflexes. The most likely diagnosis is Acute intermittent porphyria Addison disease Guillain-Barre syndrome Hyperthyroidism Systemic lupus erythematosus Hint Which of the following is NOT associated with eosinophilia? Parasitic diseases. Hay fever. Felty´s syndrome. Pemphigus. Polyarteritis nodosa. Hint A 28 year old woman presents with hemolytic anemia. Her hematocrit is 20%. Examination shows an enlarged spleen, jaundice, and reticulocytosis. Coomb´s test is normal. Spherocytes were seen on peripheral smear. Her grandmother had a similar hemolytic anemia. The definitive treatment for this disorder is Blood transfusions Splenectomy Plasmapheresis No available treatment Bone marrow transplant Hint Which of the following is NOT a red blood cell characteristic in hereditary spherocytosis? The life span of the red blood cell is reduced to 150 days. The degree of spectrin/ankyrin deficiency correlates with the degree of spherocytosis, as measured by osmotic fragility. Defects in protein 3 are present only in the dominant form of the disease. As red cells age, they slowly lose portions of the lipid bilayer. "Splenic conditioning" accentuates the membrane loss. Hint A patient under treatment for leukemia develops unilateral flank pain. Radiography shows a dilated renal pelvis and dilation of the upper one third of the corresponding ureters. Which medication could have prevented this complication? Probenecid Colchicine Acetylsalicylic acid Acetaminophen Allopurinol Hint A 20 year old college student presents because of a progressive growth on her jaw that has been getting larger over the past 8 weeks. She is an exchange student from Africa. Biopsy of a firm 5 cm tumor on the left lateral aspect of her mandible shows neoplastic B cells with frequent mitotic figures and a "starry-sky" appearance. The microorganism causing this disease is also associated with Bladder carcinoma Cervical carcinoma Hepatocellular carcinoma Kaposi sarcoma Nasopharyngeal carcinoma Hint A 22 year old male has episodic nausea and abdominal pain. Symptoms have been attributed to irritable bowel syndrome. Exam is normal. Labs show Hb of 12.2 g/dL, MCV of 92 fL, WBC count of 6.5 x109/L, platelet count of 310 x109/L, reticulocyte count of 5% (0.5-2.4), and bilirubin of 42µmol/L. AST and ALP are normal. Coomb´s test is negative and haptoglobin is undetectable. The likely diagnosis is Acute intermittent porphyria Dubin Johnson syndrome Gilbert´s syndrome Hereditary spherocytosis Viral hepatitis Hint A 25 year old female presents with fever and rigors for 2 days, fatigue, headache especially retro-orbital and diarrhoea. She has weakness of the left side of her face. She returned from a sabbatical in Uganda 4 weeks ago. She is febrile, has mild left facial nerve palsy, lymphadenopathy in her axillae and groin and has an erythematous, maculopapular rash. Her Hb is 12.0 g/dL, WBC count is 3.0 x109/L, platelet count is 150 x109/L and blood film shows lymphopaenia with some atypical lymphocytes. The most likely diagnosis is Acute HIV infection (seroconversion illness) Dengue fever Infectious mononucleosis Typhoid fever Viral hepatitis Hint If a patient with chronic renal failure is treated with erythropoietin (EPO), what would be expected in this patient? Decreased pure red cell aplasia Decreased risk of hypertension Decreased risk of thrombosis Increased well being Reduced appetite Hint In a 45 year old male with haemochromatosis, which condition is most likely to be reversible following venesection? Arthropathy Cardiomyopathy Cirrhosis Diabetes Mellitus Hint Concerning immune cell antigen receptors the FALSE statement is which one of the following? Affinity maturation of the B-cell receptor is an IMPORTANT process initiated during the primary immune response IgD are surface receptors of B-lymphocytes In normal individuals T- lymphocytes with T-cell receptors (TCR) that recognize auto-antigens are all deleted to prevent autoimmunity TCRs with different antigen specificities can be co-expressed on a single T lymphocytes The antigen specificity of the T-cell receptor is generated during development Hint Time's up Submit a Comment Cancel replyYour email address will not be published. Required fields are marked *Comment * Name * Email * Website Save my name, email, and website in this browser for the next time I comment.
